A Phase I study of the novel immunomodulatory agent PG545 (pixatimod) in subjects with advanced solid tumours

In this research article published in the British Journal of Cancer in 2018, the authors conclude that PG545 (pixatimod) demonstrated a tolerable safety profile, proportional PK, evidence of immune cell stimulation and disease control in some subjects. Taken together, these data support the proposed mechanism of action, which represents a promising approach for use in combination with existing therapies .

Immunomodulatory activities of pixatimod: emerging nonclinical and clinical data, and its potential utility in combination with PD-1 inhibitors

In this research article published in the Journal for Immunotherapy of Cancer on 14 June 2018, the authors discuss how Pixatimod modulates innate immune cells but also enhances T cell infiltration in combination with anti-PD-1 therapy.